An internationally renowned scientist at Harvard Medical School, one of the most influential figures in Time magazine, and the best-selling book Life: Why We Aging — — And why we don’t have to age, David Sinclair (David Sinclair), an anti-aging tycoon, followed NMN and resveratrol to promote another life-prolonging anti-aging substance on Twitter — — α -ketoglutaric acid (AKG)
The "epic" anti-aging substance AKG can actually reverse the "aging clock" for 16 years.
On September 1st, 2020, the world’s first professional research institute on aging — — Barker Institute of Aging published the research on AKG’s anti-aging in Cell Metabolism, and the title of the paper was "alpha-ketoglutarate, an endogenous metabolite, stretches lifespan and compressors in aging mice". The content is as follows: Experiments show that AKG can reduce the biological physiological age by 8.5 years on average, and even by 16 years at most. These results are based on the clinically relevant markers of healthspan, which is the first time in the research involving mammals.
Image from cell metallurgy, 2020, doi: 10.1016/j.cmet.2020.08.004.
The so-called AKG means α Alpha-Ketoglutarate (AKG), an important metabolic intermediate in the tricarboxylic acid cycle, is a key node connecting carbon-nitrogen metabolism in cells. AKG determines the overall rate of trihydroxy acid cycle. AKG can regulate longevity by affecting mitochondrial function, inhibiting mTOR signal, inhibiting ATP synthase expression and indirectly activating Sirtuins protein.
As early as 2014, AKG attracted people’s attention as a possible anti-aging tonic. At that time, the research report of the British magazine Nature said: "Adding α -Ketoglutaric acid can prolong their life by about 50%. "
Professor Brian Kennedy, a genetic biologist who is the main person in charge of the project, said: "We screened dozens of compounds related to aging, and the last molecule that jumped out was α -Ketoglutaric acid, so I finally decided to carry out further research that is not as good as animals. "
According to the interim data published in the first half of this year, about two-thirds of the subjects showed the effect of reducing life expectancy, with an average life expectancy of 12% and an average incidence of 46%. According to the final experimental data, the subjects fed with AKG scored more than 40% higher in the "weakness" test, which was based on 31 physiological attributes, including hair color, hearing, gait and grip strength.
It is worth noting that the life span of female mice in the experiment is 8% to 20% longer than that of the control mice, and if compared with humans, it is equivalent to extending the life span by up to 16 years.
And then professor Brian KennedyAnother heavy experimental result published in Nature further proves the influence of AKG on human anti-aging.
In the experiment, Professor Kenney’s team organized 42 middle-aged and elderly people (with an average age of 63 years) to supplement for 7 months.AKG and vitamin compound preparation. Seven months later, the researchers re-measured the physiological indexes of this group of middle-aged and elderly people. The results showed that after 7 months of AKG intervention,The physiological age of this group of middle-aged and elderly people is 8 years younger on average.. At the same time, the participants’ sleep quality and other indicators have also improved significantly.The energy level jumped by about 50%.
Professor Kenney believes that this result confirms his initial guess: "In a sense, the level of AKG will decline with age. So we need to supplement it and let the body return to a younger level. "
At the same time, he also cautiously indicated that AKG needs further experiments to develop in view of the objective problems such as the small number of samples in this experiment.
Unlock the time code and refuse to grow old meekly.
Professor Kenney once said with confidence: "There is no reason why you can’t be interfered when you get old" and "Please don’t meekly accept getting old".
There is still a long way to go to study AKG, and how to use it better is the focus of people’s attention. It is reported that AIBORST (Albers Special), a well-known American anti-aging brand, recently announced the news that its first dietary supplement with AKG as the main body, Gene Kangyuan AKG18000, will land in the China market. I believe that in the future, with the deepening of AKG research, a new era that belongs to the health of the whole people and is rooted in anti-aging will soon open.
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