Minions, stop being cute! On the counterattack of Chinese "big" animation

The word-of-mouth of the series on Douban is on the decline.


Special feature of 1905 film network In the summer, cartoons have been "marching" to the big screen one after another. Since July, 1-2 animated films have been released every week on average. Among these films, two have attracted the attention of fans — — One was released for 11 days and earned 780 million box office, while the other was the first "self-rated" Chinese animation. Now it has been released for nearly a week and the box office is less than 40 million.

 

However, in terms of word-of-mouth performance, the word-of-mouth of Despicable Me series has been declining continuously. The first douban scored as high as 8.5, and the rotten tomatoes in North America have maintained 81% freshness so far. When it comes to "Daddy Thief 3", the freshness of rotten tomatoes is barely 61%. The author interviewed several audiences at random, and most people only remembered Minions’s stupidity, but they were not impressed by the plot. Many fans commented that "the value of the series has been sucked up" and "it is really unnecessary to continue the series of hard-hitting sequels based on a popular character" … …

 

Douban netizens’ comments on "Daddy Thief 3"

 

Despicable Me came out from the first book, and formed its own routine with the type of anti-crime. The hero Gru was originally a thief, but he was always caught in the PK with other thieves. After each PK, he became an assistant to help the police solve the case. Even after the end of the second film, Gru was promoted to be an agent. When I thought that the anti-crime film was completely subverted, the third part added a new role — — Gru’s twin brother — — Drew, who wants to be a big bad guy, the game between the two brothers has become a point of view. However, with the addition of new characters, the whole film is still reduced to the pattern of anti-crime films, which has not been extended in depth.

 

 

In the movie, the most eye-catching thing is Gru’s assistant — — Minions. This is a group of yellow capsules that love bananas. They are bent on doing bad things with Gru, but they always make a sharp contrast by screwing things up. In the whole series, Minions’s setting is to pursue the nonsense contrast, and use this as an allegory to continue the unruly rebellious spirit in the first film.

 

 

With the overdevelopment of this series, Minions’s supporting roles are becoming more and more out of place, which is more like the existence of selling cute to ease the atmosphere of the film when the rhythm needs to be adjusted. Even the foreign movies are no different from the Despicable Me series except that their origins are explained at the beginning.

  

Minions’s sprouting became the performance of arresting people in this series of movies, but it gradually separated from the movie plot and became an expression pack instead. Compared with the same period of "The Great Protector", it is completely a film that is out of the routine and has ideas from the beginning.

The Great Protector may not be good enough, but it is an improvement.

 

We focused our attention on the Great Protector, and its douban score has risen from the initial 7.4 points to 8.2 points, which is the same as the evaluation in 2015. This is a very rare achievement for Chinese animated films. investigateGood lines, excellent painting skills, solidofMetaphorical content makes this animated film one of the high-quality summer movies.

 

The film takes the great protector’s search for the prince as an opportunity to come to a strange town called "Peanut Town". The whole story takes place in this small town, and the film is a dystopian story. Some people also commented that "this is the most extraordinary thing from 2017 to now, which is neurotic and negative, anti-ideal, anti-society, anti-humanity, anti-value, anti-children and anti-literature" and "even in Hollywood, it is difficult for us to see an animation with such a complex and dark theme. It is a very unique existence. Although it is not perfect, it is such an alternative and unique existence. It is unclear and can only be understood, but cannot be expressed." … …

 

Douban netizens’ comments on the Great Protector.

The director doesn’t think that from the flash era in 2004, he began to make animated short film series, including representative works "Blackbird" and "Millet Forest". Although a minority, it has long been famous in the animation circle. In the early works, we can already see the unique aesthetic of not thinking about the world. For example, in the role setting, I prefer to take the dark and strange style; In terms of content and line style, it is different from many animations of young teeth. Especially "Millet Forest", although each episode is only a few minutes, the director has constructed a very complete world view. These advantages have been continued in the Great Protector.

 

The animated series "Millet Forest"

 

In his early years, the director made his debut as a short drama series, tried a long animated film for the first time, and even invited the best editing of the golden statue — — Lin Aner participated in the production and editing. The director himself does have a lot of demands and things he wants to express. With Lin Aner’s "Golden Scissors", while ensuring the director’s authorship, he has done a strong control in editing and ensured the rhythm of filming.

 

On the Style of "Prince"

The most interesting, but controversial, part of The Great Protector is the style of lines. The lines in "The Great Protector" almost violate the cognition of many mass audiences on animation, and even feel a little "don’t talk to people". On the contrary, fans think that the lines are all designed and are the director’s own style. From the perspective of unfamiliarity, the balance of these lines is actually that what he wants to do is not a safe film that the public thinks is not a problem, but a fresh work.

 

In the pursuit of fresh and independent style, the Great Protector succeeded. Although this is an animation with a violent shell, many viewers laughed with the film during the premiere. One second, the film is still orthodox, and the next second may be the sun and the direction, which is described as "collapse" in animated terms.

 

Violent scenes in the Great Protector

In particular, the role of "Prince" in the film is completely handled according to Japanese and Japanese styles. The identity of the prince sounds like a high-end orthodoxy, but in the movie, it has completely become a joke. Because the director likes Xu Jinjiang’s role as "the leader of Yue Bai" in The Legend of the Sword and the Chivalrous Man, the modeling of "Prince" directly refers to Xu Jinjiang himself. The prince is narcissistic and lofty, and shows his indifference to the world. Although his face is full of stubble and looks fierce, he is talkative and sensitive to literature and art.This "sense of collapse" is not a kind of out-of-control meaning, on the contrary, it is a unique style of animation, which brings a refreshing contrast to the audience.

Next page:This is the best time for Chinese animation, but it is also full of crisis.

Jay Chou halo blessing, why can’t it be the second "Initial D"


Special feature of 1905 film network When it comes to racing movies, it was definitely a generation of memories of youth who was all the rage 16 years ago. Fujiwara Takumi, a fledgling city, and AE86, which drifts wildly on the famous autumn mountain, still impress many viewers.


Regrettably, amid the anticipation, we never expected a sequel to it, and we were temporarily unable to solve the suspense left by that year.


Recently, the producer, directed by Yixian Chen, starring,, and especially starring have been released.


It is noteworthy that the same racing theme, the same familiar Jay Chou.Whether it’s the "Tofu" in the playSalute, or off-stage, he gave AE86 to "idolize Winner".Wang JunThere is still a lot of linkage between Kay’s fable, All-powerful Storm and Initial D.


Arguably, the visual impact of racing movies, coupled with the blessing of Jay Chou’s aura, is still a bit interesting. But unfortunately, whether it is word of mouth or box office, it failed to replicate the glory of the past.


Why don’t the audience like watching it?


Douban scored 4.8, and the box office was just over 4 million, which was the result of the five-day release of All-powerful Storm. This performance is not worth mentioning at all compared with Initial D, which ranked sixth in the total box office in 2005.


No matter whether it is or not, films of the same kind that hit the box office are always willing to create the image of "burning blood", and the new work supervised by Jay Chou is no exception. But looking at the whole film, its performance is really difficult to prop up the corresponding stunt.



Director Yixian Chen admits that in order to remember the father who enlightened his car through movies, the story of Lao Shen and his son A Shen in the play is full of the shadow of himself and his father. In addition to family, the film’s excavation of the initial heart of the male owner Dujak’s racing car lies in his love for Lily; As for the root of the conflict with villains, it is rooted in the friendship break between Li Yifei and Song Jie, who used to be teammates.


Family, love and friendship go into battle together, and it is understandable to promote the development of the plot with rich emotional changes. However, the description of these feelings in the film has not been deeply explained and explored, and only a few strokes have passed by. Even the audience who have seen the film probably cannot resonate with it.


In addition, the process of the simulator champion becoming a real track champion is also described a little rough and deliberate. Especially when the theme of racing is put aside, All-powerful can be regarded as a story of a man’s "power generation for love", which is based on a weak plot and simple emotions. To some extent, it is difficult to talk about "blood".


Even in the racing scenes that can best arouse the audience’s emotions, the director tried his best to restore the exciting scenes of racing competition through multiple scenes, but the reason why the plot design helped the team win was based on the driver’s early judgment on rainy days. In the absence of clear foreshadowing or subsequent explanation, such an unpremeditated plot became a failure that the film could not ignore.


Undeniably, as a former professional racing driver, Yixian Chen has a deeper understanding and experience of professional racing than ordinary directors. The film covers a wide range of industry topics such as fleet operation and schedule strategy. Under the guarantee of sufficient investment, all kinds of "cool spots" such as "racing" and "falling" of burning money are also portrayed.


However, perhaps because he was an advertising director, Yixian Chen didn’t seem to have the thinking and method of shooting short films, and lacked the use of long shots and proper close-ups. Many shots that should have caused adrenaline surge were also complained by the audience that it was difficult to really get excited.



In the end, "large-scale MV" has become a concise review of fans; Not being loved by the public has also become the dilemma faced by All-powerful Storm.


Why don’t fans buy it?


The film quality is the key point that affects the market box office, but not all factors.


Some time ago, thanks to the excavation of the sinking market and the precise marketing of potential audiences, Douban scored only the sum of 3.5 and 4.1, and its box office performance still exceeded 100 million. This means that works that meet the pain points of potential audiences and have poor word-of-mouth performance still have the opportunity to turn over and counterattack.



As mentioned above, the quality of "All-powerful Storm" is doomed to be difficult to get out of the circle.


Jay Chou has a strong influence, his every move, can easily board the forefront of hot search. As a "living signboard" of "All-powerful Storm", he also contracted most of the heat sources before the film was shown with his own voice.


In fact, although he was a producer, guest star and personally composed music for the theme song, his appearance in the film was also very short. In the eyes of fans, this is just the name of the idol on the surface. The core of the real performance has little to do with it, so it is certainly not necessary to spend it.


Anyone familiar with Jay Chou knows that he often participates in film creation because of his interest. Starring "Initial D" because of car love; Starring because he likes basketball; Self-directed and self-directed because he likes music.


But it is a pity that, with the exception of "Initial D" and "Unspeakable Secrets", its screen performances are not remarkable, and Qi Fei’s masterpieces with word-of-mouth and box office are not produced much. However, although Slam Dunk and Love on the Rooftop have a general reputation, the box office of both films has also exceeded 100 million yuan, which, to a certain extent, also shows Jay Chou’s box office appeal.


Admittedly, this does not mean that fans can accept holding high Jay’s banner and playing "edge ball".


It’s not difficult to find out from Jay Chou’s resume that "All-powerful Storm" is not the first time he has been named as a producer of "bad movies". Four years ago, it also featured in the name of "Jay Chou Producer", but in the end, Douban scored only 4.6, and the box office did not exceed 4 million. It can be seen that Jay Chou has a strong appeal, but also has a group of savvy fans.


The lesson of "The Agreement of 10,000 Kilometers" will make fans hesitate to place an order to watch movies. At the same time, as countless idols born in the 1980s and 1990s, Jay fans are getting longer and longer with the years. At the same time, they are more mature and rational, and it is difficult to buy "bad movies" named after idols.



Back to "All-powerful" itself, looking at the film’s creative team, Jay Chou is the producer, his best friend is the producer, his wife Hannah Quinlivan is the heroine, and his younger brother Karry is the special star. In the words of fans, this is a "Jay Chou Friends Circle Movie", which is a work tailored by Jay for his wife.


Perhaps, if Hannah Quinlivan’s performance is awesome, it’s natural for fans to love me, love my dog. But unfortunately, she didn’t surprise everyone and couldn’t attract fans. Her poor acting skills were even discouraged by everyone.



It is worth mentioning that some senior fans have also expressed another view. From the variety "Travel Notes of the Week" to the movie "All-powerful Storm", Jay has often appeared in public with relatives and friends in recent years.


As fans, they can understand the idol’s mentality, but they don’t accept the works that are not centered on Jay Chou and start to consume the aura he has accumulated for many years. In the eyes of fans, they are still looking forward to seeing Jay’s new attempt, but they are unwilling to support his over-consumed works.



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Just as Jay Chou didn’t become the lifeline of All-powerful, the core of winning in the market, regardless of the publicity stunt of any work, is the quality of the film.



Take the National Day in 2018 as an example, the main theme is to continue the Mahua FunAge style and the charm of "Shen Teng", and the box office before the screening is expected to be as high as 2.5 billion+. However, after the release, it was vomited by a large number of audiences because the goods were not right. The word-of-mouth of the film Douban plummeted from 5.9 at the opening of the painting to 4.6, and the film arrangement rate dropped from 35% on the first day to 20%. Finally, the box office stayed at 600 million, far below the box office expectations, and even less than half of the previous box office.



In the final analysis, the audience is more willing to enter the theater for high-quality content. Beyond gimmicks, works should return to the essence of creation. Only in this way can our film develop positively.


International Confucian Forum: Contributing China Wisdom to Human Peace

  The "International Confucian Forum 2019" sponsored by China Renmin University and Cui Zhongxian Academic Institute was held in Qufu, Shandong recently. The theme of the forum is "Confucianism and human peace". More than 150 scholars from home and abroad attended the meeting. The conference received a total of 124 academic papers. During the two-day meeting, besides the General Assembly, there were 24 breakout sessions. Harmony, harmony and peace are the basic ideas of Confucianism; It is the basic attitude of Confucianism to be neutral and harmonious but different; Protecting harmony and peace in the world is the fundamental pursuit of Confucianism. In the 21st century, Confucianism will continue to provide an oriental solution for human peace and contribute to China’s wisdom.

  The concept of "harmony" has a long history in Chinese culture, and it came into being with the beginning of civilization. In Zhouyi and Shangshu, there have been rich meanings of "harmony among nations" and "safeguarding harmony and harmony", and Confucius, the founder of Confucianism, formally established a cultural pedigree of noble harmony, advocating harmony and respecting harmony, which became the core characteristics of Confucianism.

  Conceptual analysis is an important path of philosophical research. When discussing the Confucian thought of "harmony", scholars pay special attention to the dialectical relationship between harmony and identity. Professor Huang Kaiguo of Sichuan Normal University and Professor Pan Xiaohui of Fu Jen Catholic University analyzed several debates on harmony and identity in Chinese history: Shi Bo’s "harmony with real creatures, the same will not be continued", Yan Ying’s "harmony as soup" and Confucius’s "gentleman’s harmony without difference", pointing out that "harmony" is the core and positive concept that can best demonstrate peace and oppose war, and "harmony without difference" is the most important practical principle. Scholars also attach importance to textual research on the concept of "harmony" from the source of the system. Professor Xie Guangyu of Anhui University took the idea of "great unification" as the starting point to sort out the concept of peaceful reunification from Huangdi’s "harmony of all nations", Yao’s "harmony of all nations", Confucius, Mencius and Xunzi to the present era. Professor Chen Hui of Macquarie University in Australia also reviewed the cultural inheritance of three generations of civilizations and early Confucianism.

  Academic concepts must interact with human beings and then be related to social life in order to have social value. "Book of Rites University" says: "After physical training, the family will be in harmony, and the family will be in harmony with the country, and the country will be in peace with the world." Confucianism, as a practical theory, realizes the transformation from the idea of "harmony is the most important" to the social idea of "human peace" through the way of being sage inside and king outside. Professor Luo Anxian of Renmin University of China examines the possibility of realizing the Confucian concept of peace from the perspective of "conscience", pointing out that Confucianism firmly believes that "conscience" exists, and human kindness is the foundation of everything; The key to human peace and world peace is the conviction and protection of conscience. Professor Li Guanghu of Yonsei University in South Korea also said that the Confucian thought of human peace is based on the goodness of the community, and the realization of the goodness of this community is based on the Confucian theory of good nature.

  Professor Zhang Liwen from Renmin University of China concluded in the keynote report "Confucianism and Peace under the World" that the Chinese nation has always pursued peace under the world, and peaceful development and win-win cooperation are the universal aspirations and aspirations of people all over the world. The concept of "harmony" contained in Confucianism has been cast into the national mentality and value pursuit of the Chinese nation, which advocates great harmony and loves peace, and it has become endless and popular.

  Confucianism, which was conceived in the war-torn Spring and Autumn Period, has been full of peace genes since its birth. The advocacy of "abandoning soldiers" by Confucius’ benevolence, the lashing of war by Mencius’ senseless war in the Spring and Autumn Period, the resolution of war by the ideal of "Great Harmony in the World" in The Book of Rites, and even the theory that Taoism, Mohism, France and celebrities stop fighting and love each other without attacking & HELIP; … Focusing on peace and exploring the solution to achieve peace from a theoretical height is an endless academic tradition of Chinese culture represented by Confucianism.

  At the forum, Chinese and foreign scholars fully tapped the Confucian ideological resources of respecting others, living in harmony, learning from each other, multi-dimensional consultation, resolving wars and pursuing peace, which provided theoretical reference for the coexistence and development of people, people and environment, people and society, nations, countries and civilizations. Professor Xiang Shiling from Renmin University of China looked at the Confucian theory of war and peace from the biography of Spring and Autumn Annals, and put forward that loving peace does not mean denying war, but the principle of justice is the most fundamental principle. Professor Lin Cunguang of China University of Political Science and Law believes that in the exchange of their respective ambitions, Confucius and his disciples all expressed a pacifist ideal of friendly interaction between people, peaceful coexistence between countries, and even self-cultivation and external security. Professor Xing Dongfeng from Ehime University in Japan sorted out Mencius’ benevolent pacifism based on people-oriented principle and internal and external affairs, and evaluated it as the Confucian orthodoxy that inherited Confucius’ thought. Professor Cai Jiahe of Donghai University has studied the contribution of Confucius and Mencius to Yangming’s "one-in-one benevolence" to human peace, and thinks that thinking about modern international and interpersonal problems based on this can contribute to the process of peace and civilization.

  The conflict between pluralism and monism, the confrontation between harmonious symbiosis and competitive game are the hidden cultural factors behind peace and war, and many scholars have conducted in-depth research on them from the metaphysical point of view. Professor Choi Young-chen of Sungkyunkwan University in South Korea compares religious pluralism with the theory of "unity and diversity" and points out that Confucianism has two sides, and the pursuit of balance is the ultimate goal of Confucianism. Chul-Seung Lee, a professor at Korea University in Korea, believes that Confucian harmonious philosophy can actively deal with the problems caused by the rejection of "difference" caused by exclusive competitive consciousness and the blind identity consciousness trying to attribute particularity to transcendental universality in the multicultural era.

  Confucianism is China’s and the world’s, and it has increasingly strong influence and appeal in the world. Observing and reflecting on the timeless Confucianism from the theoretical level and strengthening the interaction and mutual learning between Confucianism and world civilization will certainly provide theoretical help for maintaining world peace and order.

  Today, with the development of world cultural diversity and economic globalization, local conflicts, terrorism and refugee crises are constantly emerging, and Confucianism, as a political philosophy, has increasingly demonstrated its practical significance for human peace. It is the mission of the times to put "Rixin" Confucianism into the political and cultural context of the contemporary world, absorb everything and learn from others, and crack the common peace code of mankind.

  First, we should promote Confucianism to "live", embrace Confucian civilization with a confident attitude, promote the creative transformation and innovative development of traditional culture, and provide useful reference for the construction of a harmonious society in China. When talking about cultural self-knowledge and cultural self-confidence, Professor Yang Chaoming, president of the Confucius Institute in China, pointed out that a virtuous country such as Beichen is in the middle, which is the cultural coordinate of Confucian civilization in the world. Scholars have innovatively expounded the Confucian thought of "harmony", or interpreted the modern meaning of Mencius’ "being kind to others" based on the virtue of a gentleman, the cultivation of political morality and the harmony of the world, or combed the order of harmony from family to clan to neighbors and even the world in ancient family rules, or obtained enlightenment for the harmonious success of modern economic activities from the concept of justice and benefit from etiquette to classical Confucianism, so as to make its cultural light fully bloom.

  Secondly, it is necessary to push Confucianism to "go global", realize the global construction of China’s humanistic discourse system in the dialogue among civilizations, and solve the problem of balancing nationality and internationality in the dissemination of Confucian peace thoughts. Professor Yun Chen of East China Normal University reflected on Huntington’s "Clash of Civilizations" and thought that the Confucian concept of peace provided another new possibility for the human world besides western civilization.

  Third, it is necessary to promote Confucianism to be "strong", draw ancient wisdom from Confucianism to resolve the peace dilemma, and provide ideological and cultural support for the construction of a world lasting peace and a community of human destiny. Professor Yin Bingnan of Xijiang University in South Korea pointed out that the construction of a community of human destiny must first establish the concept of peaceful development ideologically. Professor Kong Deli of Beijing Jiaotong University analyzed the value of the Confucian tradition of Concord, Harmony and Harmony to contemporary China, and put forward that the "Belt and Road" strategy and the new development concept of Eurasian destiny community are behind the strength of Confucian tradition. Professor Huang Yushun of Shandong University put forward the concept of "the community of human civilization" on the basis of the community of human destiny, emphasizing that Confucianism can contribute important values to the construction of a singular human common civilization facing the future. All this is the contemporary practice of Confucianism promoting human peace.

  The International Forum on Confucianism was founded in 2004 and has been held for 14 consecutive sessions. The theme of the forum is distinct, exploring and studying the true meaning of Confucianism, and deeply excavating the modern value of Confucianism. Now it has developed into a Confucian grand event with important international influence.

Health and Health Commission responds to the tight supply of influenza vaccine: the overall supply and demand are basically balanced now.

  Cctv newsOn January 25th, a press conference was held in National Health Commission to introduce the prevention and control of infectious diseases in winter and spring and the prevention and response of common diseases during festivals. When answering a reporter’s question, Lei Zheng Long, deputy director of the National Health Commission Municipal Bureau of Disease Control and Prevention, said that with the successive arrival of vaccines, the supply has been basically balanced.

  Reporter: It is reported that after the vaccine incident last year, there was a shortage of influenza vaccine supply in our country. Is there any data or what it is? Are there any measures to improve it?

  Lei Zheng Long: Because the vaccine manufacturers’ acquisition of influenza vaccine strains from the World Health Organization and the purchase of standard reagents were delayed by two months compared with previous years, the relevant work was delayed accordingly, which led to the time when influenza vaccines were started in previous years, and there were cases where vaccination sites had not yet started. However,With the subsequent arrival of vaccines, the current supply has been basically balanced.

  According to our statistics on the use of influenza vaccine,At present, 14.26 million vaccines have been purchased and 10.97 million vaccines have actually been vaccinated, which means that some vaccines have not been vaccinated this year. So now the overall supply and demand are basically balanced.

Flash! CDE issued the Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin.

      In order to standardize and guide the R&D, production and registration of specific human immunoglobulin, and further clarify the technical evaluation standards, under the deployment of National Medical Products Administration, the Drug Testing Center organized and formulated the Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin (see Annex).
       According to the requirements of the Notice of the General Department of National Medical Products Administration on Printing and Distributing the Release Procedures of Drug Technical Guidelines (No.9 [2020] of the General Administration of Drug Administration), with the approval of National Medical Products Administration, it is hereby promulgated and shall come into force as of the date of promulgation.
       This is for your information.

       Appendix: Technical Guiding Principles for Pharmaceutical Research and Evaluation of Specific Human Immunoglobulin
National Medical Products Administration yaoshen center
May 20, 2022   
I. Overview

Specific human immunoglobulin (HIG) is a highly effective immunoglobulin preparation prepared from plasma containing specific antibodies.

The sources of plasma include plasma with high titer antibody after the patient recovered from infection with a pathogen, and plasma containing specific antibodies by hyperimmune injection of healthy blood donors, that is, injection of vaccines or other antigens to make the injected people produce antibodies. Specific human immunoglobulin (hereinafter referred to as "special immune product") is an indispensable blood product because it contains specific antibodies with high titer, and its effectiveness in preventing and treating specific diseases is better than that of ordinary human immunoglobulin.

In order to encourage, standardize and guide the research and development of special exemption products, this guiding principle is formulated with reference to the relevant technical requirements at home and abroad and combined with the actual situation in China. This guiding principle is only based on the current technical development and scientific cognition, aiming at the general pharmaceutical research technical requirements of special exemption products. The applicant/holder can also adopt other more effective methods and means according to the actual situation of the research and development of the exempted products, but it should conform to the law of drug research and development and provide scientific and reasonable basis to ensure the safety, effectiveness and controllable quality of the products. 

Second, the scope of application 

These guiding principles are applicable to the special immunity products made of specific antibody plasma obtained by direct screening of specific antibody of plasma donors and active immunization. They have similar product characteristics and pharmacological characteristics, and their pharmaceutical requirements are both common and different. At present, the varieties included in People’s Republic of China (PRC) Pharmacopoeia (hereinafter referred to as China Pharmacopoeia) include hepatitis B human immunoglobulin, rabies human immunoglobulin, tetanus human immunoglobulin, etc. The research and development and registration of special exemption products at home and abroad are shown in Schedule 1, and the modes of administration are divided into intravenous injection, intramuscular injection and subcutaneous injection.

III. General principles 

1. Security. 

Because of the particularity of blood products, there is a potential risk of virus pollution, and virus safety control is the core content of blood products quality control. The collection, inspection, storage, transportation, traceability and the immune requirements of plasma donors of the plasma exempted products shall conform to the provisions of "Plasma for Blood Products Production" in China Pharmacopoeia and "Quality Management Standard for Plasma Collection Stations". It is suggested that screening research on B19 and other pathogens should be carried out according to product characteristics and clinical users, especially some special varieties (such as anti-D immunoglobulin). It is suggested that the applicant/holder cooperate with relevant departments to carry out epidemiological monitoring in the area where the plasma station is located. Actively promote the detection technology of nucleic acid in raw plasma and mixed plasma, and formulate standards and requirements. Special attention should be paid to the epidemic situation and detection methods of new and sudden infectious diseases.

2. Specific antibody screening. 

The accuracy and reliability of specific antibody screening results is the key to ensure the quality of raw plasma. In the case of large-scale production, the amount of single plasma detection involved is large, so it is necessary to establish a suitable antibody titer detection method and fully verify it by the method in the early stage of research and development. Single plasma can be screened for specific antibodies by immunolabeling method, and the correlation between binding titer and neutralization titer can be established. The combined plasma, stock solution and preparation shall be tested for specific antibodies by the method specified in China Pharmacopoeia or the verified method. Usually, based on virus neutralization test (mouse neutralization test, micro-cell lesion count and plaque reduction test), immunolabeling test (enzyme labeling, fluorescence labeling, isotope labeling, etc.), hemagglutination inhibition test, immunodiffusion test, immunoturbidimetry test or other immune/biochemical tests, the research is carried out by quantitative and semi-quantitative methods based on reference materials.

3. Production technology 

The process development of this kind of products can refer to the process of similar products that have been listed, and platform technology can be used. The use of chromatography is encouraged to improve the purity of products, but the selection of chromatographic parameters and the influence of the quality of chromatographic resin on the quality of products should be fully considered, and the inactivation and removal ability of viruses by the process should be paid special attention to. The verification of virus inactivation/removal should meet the requirements of General Principles of China Pharmacopoeia "Virus Safety Control of Biological Products", "Technical Methods and Verification Guidelines for Virus Removal/Inactivation of Blood Products" and technical documents such as ICH and WHO.

Management rules and operating procedures should be established for personnel safety protection and wastes in the production process, bioactive substances and viruses should be inactivated according to proven inactivation treatment methods, and effective protective measures should be taken to protect operators to avoid risks such as virus transmission.

Four, pharmaceutical research and evaluation points 

(1) Raw plasma and materials for production 

1, plasma source and quality control 

Quality control of single plasma: single plasma must meet the relevant quality control requirements issued by the national health administrative department. Raw plasma used for production must have legal sources (plasma station certification documents, etc.) and pass inspection and quarantine, and should have complete reagent data (marketing certification documents, etc.) and screening records (antigens/antibodies/nucleic acids) for screening blood-borne infection markers.

Immune procedure: immune procedure and dosage of antigen used are the key factors to determine the concentration and titer of antibody in plasma. It is necessary to define the immunization methods. For example, when active immunization is carried out with approved vaccines or other antigens, these immunogens should have complete source certification information and batch information. The immunization program should refer to the requirements of vaccine instructions, or be formulated according to the immunogenicity of antigen and the reactivity of plasma donors, but the specific immunization program adopted should prove its safety. Subjects should have full right to know, and at the same time make corresponding countermeasures for possible problems. 

Quality control of mixed plasma: A certain amount of plasma should be mixed, which should meet the requirements of China Pharmacopoeia in combination with product characteristics. At present, ordinary people are required to mix the plasma of at least 1000 plasma donors. Specially exempted products generally require plasma mixing from at least 100 plasma donors, except for some special varieties (such as anti-D immunoglobulin products).

No matter the plasma obtained by active immunization with approved vaccine or immunogen or the plasma immunized after natural infection, the specific antibody content standard of each plasma and combined plasma should be formulated at the time of IND declaration. The plasma whose antibody level is up to the standard is used for plasma production. For varieties that have not been recorded in China Pharmacopoeia, there should be a clear basis and a proven detection method for determining the titer of specific antibodies in raw plasma and preparations. When NDA is declared for the varieties included in China Pharmacopoeia, the antibody titer standard should not be lower than the requirements of China Pharmacopoeia.

2. Raw materials for production 

Strict quality control of raw materials used in the production of special exemption products is a necessary measure to reduce the risk of contamination by exogenous factors or toxic impurities in products and avoid the activation of other factors in plasma. In addition to clear sources, quality standards and inspection reports, raw materials for production should also focus on the use of animal-derived raw materials (such as heparin) and avoid using animal-derived raw materials as much as possible. TSE/BSE risk assessment should be conducted for raw materials used in production. 

When using filter AIDS (perlite, diatomaceous earth, etc.), filter membranes and filter element materials in the separation process, it is necessary to establish appropriate quality control standards according to the requirements of different process stages, control the introduction risk of exogenous factors, control bacterial endotoxin and heavy metals, and formulate reasonable limit requirements. In addition, it is necessary to pay attention to the risk of residues that may be mixed into the final product and potentially harmful to human body, and control them if necessary.

(2) Production technology 

1. Stock solution 

The initial raw material of the special immunity products is raw plasma or plasma components. The modified Cohn method or KistlerNitschmann method can be used to separate the special immunity products, and other methods can also be used for separation and purification, such as octanoate precipitation and chromatography. 

The separation and purification process adopted should ensure that the physicochemical and biological properties of the product and the biological activity of the Fc segment of IgG are well preserved. The production process must avoid or eliminate the pollution of microorganisms (bacteria, viruses) and their metabolites (pyrogens) to the maximum extent. It is necessary to strengthen the control of production process and consider the influence of the removal of filter AIDS and the selection of filter media on the products. It should be paid attention to that IgG fractions obtained by different separation methods may contain higher levels of IgA and IgM. At the same time, attention should be paid to the rationality of sterilization and filtration steps, and the integrity of the filtered membrane should be checked.

It is necessary to specify the amount of slurry for pre-clinical, clinical samples and market-scale samples. Generally, continuous production should be carried out, and the production capacity of each process step should be matched with each other, and the processing should be completed at one time. In each process step, it is the key to determine the process control parameters and scope and meet the requirements. When using ethanol and other precipitation methods, it is necessary to control the quality of ethanol and other reagents, and study the protein concentration, temperature, pH value, ionic strength, treatment time and so on, so as to define the acceptable limit range. In the process of dissolution and precipitation of plasma components, avoiding IgG coprecipitation is the key to improve the product yield, especially the key indexes such as temperature and adding time should be fully studied to investigate the influence on the key quality indexes such as protein purity and molecular size distribution. When chromatographic method is used, it is necessary to optimize chromatographic conditions and determine reasonable parameters according to the nature and concentration of protein in the product, such as the capacity of chromatographic column, ionic strength of feed solution and buffer solution, pH value of buffer solution, flow rate, contact time and temperature, etc. The determination of these parameters should be based on the research data of process development, and limit standards and allowable ranges should be formulated. At the same time, it is necessary to study the cleaning and regeneration (service life) of chromatographic resin, the load of chromatographic column and the extract, especially the use of chromatographic packing with potentially harmful ligands. It is necessary to pay attention to the volume, protein concentration, recovery rate and electrophoretic purity of each separation and purification step, and evaluate the process-related impurities (such as ethanol, sedimentation aid, IgA, aluminum, heavy metal ions, etc.) and product-related impurities.(such as polymers, etc.). If necessary, in order to prove the ability of the process to remove impurities, it may be necessary to use standard addition test to evaluate the ability of the process to remove some potential pollutants. If operations that may affect product quality, such as temporary storage and transportation of intermediate products, need to be supported by necessary stability research data.

Encourage the use of innovative and improved processes (including the improvement of ethanol separation process) to improve the utilization rate of plasma and improve the quality of special exemption products. In the early stage of process development, attention should be paid to the identification of key process parameters, the integrity of process control in different separation stages and the rationality of process parameter setting. If the applicant/holder has already marketed products with the same separation and purification process, and the existing process research data and control parameters can be used for reference, the process verification of three batches of new special exemption products should be carried out. 

Considering the preciousness of plasma resources, the pilot-scale research data suitable for clinical trials can also be used for the declaration of IND stage. However, when applying for NDA, it is necessary to have complete commercial scale research data.

2. Preparation 

Clarify single prescription and batch prescription, and explain the basis of rationality of preparation prescription. Auxiliary materials suitable for medical use should be used, and the stability of the supply chain should be ensured. For accessories from multiple suppliers, it is necessary to carry out full research. For brand-new excipients that have not been used in similar preparations at home and abroad, a comprehensive study should be carried out and related declarations should be made. No bacteriostatic agent shall be added to the special exemption products for intravenous injection. Because some cosolvents (such as polysorbate 80) have the potential risk of causing allergic reaction and hemolysis reaction, safety evaluation should be carried out. The preparation process (such as stirring speed) should be studied. In principle, the preparation of semi-finished products should come from a batch of stock solutions. If different batches of stock solutions are used to prepare semi-finished products, the possible risks should be evaluated.

The temperature of products, the duration of packaging, the temperature and humidity of packaging environment should be controlled. Special exemption products involving freeze-drying technology should have data such as freeze-drying process parameters and freeze-drying curves verified by commercial batches, indicating the influence of freeze-drying technology on product quality, especially on biological activity.

3. Process verification 

For the products exempt from intramuscular injection, it is necessary to determine the process flow and key process parameters before NDA declaration, and continuously produce three batches of products to verify the stability of the process, so as to provide a supporting basis for the products to go on the market. For the special exemption products for intravenous injection, the process flow and key process parameters should be determined as far as possible before the confirmatory clinical trial, and the stability of the process should be verified by continuous production of three batches. If there are differences between clinical trial samples and commercial scale batches in terms of production technology or site, it is suggested to carry out change research, and it is suggested to carry out research and exploration on the worst process conditions at an appropriate stage, and it is necessary to prove that qualified products can be produced under the determined process parameters and quality control limits. If multiple production sites or production lines are involved, verification research should be carried out. 

(III) Virus safety and virus removal/inactivation verification 

The detection of single plasma and mixed plasma should meet the requirements of China Pharmacopoeia, and the number of cases of mixed plasma should meet the sensitivity requirements of the kit/detection method. For anti-D immunoglobulin, the nucleic acid load of B19 virus in plasma should be ensured to be less than <104 IU/ml.

Because of the differences in the ability of inactivation/removal of lipid-coated and non-coated viruses by various methods, it is recommended to use two virus inactivation/removal methods with different mechanisms to carry out verification, and to clarify the technical conditions and control parameters of virus inactivation/removal process steps, including product uniformity, upper and lower temperature limits, inactivation time, filtration pressure/speed/temperature/solution composition/membrane integrity, etc. Attention should be paid to the rationality of setting the position of deactivation/removal process steps. When selecting virus removal/inactivation method, the effect of virus inactivation/removal should be balanced with product activity and general safety. 

It is necessary to consider the potential interaction between inactivation steps, the influence of inactivation process on antibody integrity and clinical efficacy, whether new immunogens are formed and the risk of toxic residues that may be introduced. If the production process changes, which may affect the virus removal ability, it needs to be verified again. In addition, the samples used for inspection should be representative of the process. With the development of technology, some new methods of virus inactivation can also be applied in special exemption products, which need to be proved to be scientific and effective and fully verified.

If the products with the same process steps have been approved and registered, and the virus inactivation/removal process has been verified, the newly declared products will only change the mode of administration, and the products with the same production equipment, process and operation as the original products in commercial batches can not be subjected to virus inactivation/removal process repeatedly on the premise of meeting the relevant technical requirements such as Technical Methods and Verification Guidelines for Removing/Inactivating Viruses from Blood Products and Technical Guidelines for Pharmaceutical Change Research of Listed Biological Products.

In order to ensure the virus safety of the final product, we should consider the setting of plasma station from epidemiological data, strictly select plasma donors, screen plasma and manage the quarantine period, optimize the production process and add virus removal/inactivation steps, and evaluate the virus removal ability of the whole process steps of producing products. To evaluate the virus inactivation/removal ability of the production process and the maximum load of specific virus that may exist in the initial plasma, and to ensure the virus safety of the product to the greatest extent, it is necessary to ensure that the verification includes the worst case.

(D) Quality research and control 

1. Analysis of physical and chemical characteristics 

It is necessary to gradually improve the analysis of physical and chemical characteristics in combination with product types, preparation types and drug development stages. IND declaration can be made based on the preliminary research data of physical and chemical characteristics, and NDA declaration should be made by comparing the physical and chemical characteristics, including antibody integrity, antibody subtype distribution, circular dichroism analysis, etc.

2. Biological activity 

Biological activity research should be fully carried out, and it is suggested to study the correlation between binding titer and neutralization titer detection methods. From the aspects of supporting the rationality of the process and considering the influence of the process on the product, it is suggested to establish a method for detecting the biological function of Fc, and to study the sialic acid content of Fc segment in the development stage. Production technology, antibody titer, IgG polymer, IgG subclass, etc. will affect the results of biological function test of Fc. In addition, it is suggested to analyze the binding ability of Fc segment to immune cell surface receptors, the activation of complement function by Fc segment, and the regulation of phagocytosis.

3. Purity and impurities 

Attention should be paid to the components that affect the function of this kind of products, and the purity is generally not less than 95%. In addition to carrying out research on impurity residues and proving the ability of the process to remove impurities, the impurity level limits of batches at different stages (if there are clinical and commercial batches) should be set reasonably. It is suggested that a sensitive method should be used to control the content of impurity protein. 

Polymers produced during the preparation of special immunity products are related to anti-complement activity (ACA), and the content of IgG polymers should be controlled. In order to prevent patients with congenital IgA deficiency from causing serious allergic reaction after using special immunity products, the content of IgA should be controlled. The content of anti-A and anti-B hemagglutinin should be studied and the limit standard should be established to prevent hemolytic reaction caused by large amount of infusion. Encourage the detection of coagulation activator levels and establish standards. It is suggested that anti-D antibody detection should be carried out for intravenous special immunity products from special plasma sources. In addition, in order to prevent the risk of thrombosis, it is suggested to control the FXIa content of intravenous special immunity products and establish standards.

Encourage the detection of other miscellaneous proteins in blood, such as kallikrein activator, immunoglobulin M, transferrin, albumin, α1- antitrypsin, α2 macroglobulin, haptoglobin, α1- acidic glycoprotein, ceruloplasmin, fibrinogen, antithrombin III, plasminogen, fibronectin and C1 esterase inhibitor.

Special exemption products, especially those for intravenous injection, should also focus on the control of insoluble particles. Insoluble particles can not be metabolized in human body, and it is easy to induce thrombosis if they stay in tiny blood vessels. The content of aluminum should be controlled. Aluminum has potential risks to the central nervous system, bones and other organs, and this risk is related to the infusion dose.

4, quality analysis and standards 

The listed special exemption products should meet the requirements of China Pharmacopoeia, and the rationality of testing items should be fully considered for new special exemption products. Quality standards should be set reasonably according to the characteristics of products with different administration methods, such as intravenous special exemption products, and FXIa factor, aluminum ion and IgA content should be increased.

When applying for IND, special attention should be paid to antibody titer, harmful residues and other related testing items.

When applying for NDA, the quality standards of stock solution, semi-finished products (if any) and preparation should be reasonably drawn up based on the data of various research and development stages and stability inspection, on the basis of statistical analysis of multiple batches, combined with the requirements of China Pharmacopoeia and the situation of similar products, with emphasis on the quality control of potency, and more stringent internal control standards should be encouraged. Advanced and mature methods should be used for titer detection, and various complementary analysis methods should be encouraged for quality control in the early stage of research and development. If auxiliary materials such as maltose, polysorbate 80 and glycine are added to the preparation, it should be controlled in the quality standard of the preparation and its content range should be defined.

5, analysis method and methodology verification 

Combined with the characteristics of products, select a reasonable analysis method and carry out sufficient methodological verification to ensure the feasibility of the method.
At the time of IND declaration, at least the preliminary verification of antibody titer and harmful residue detection method should be completed.

When applying for NDA, a complete analysis method should be established and verified. Clarify the accuracy, precision (including repeatability, intermediate precision and reproducibility), specificity, detection limit, quantitative limit, linearity, range and durability of the determination method. Methods other than those in China Pharmacopoeia should be fully verified when applying for NDA. If the determination method is changed greatly, the scope of re-verification should be determined according to the degree of revision of the method.

Establishment and verification of antibody titer detection methods: research on product-specific antibody titer detection methods and standards should be carried out before research and development. It is suggested to study the correlation between binding titer and neutralization titer detection methods. Try to use the method of China Pharmacopoeia, and try to choose the classic and industry-standard method for those not included in China Pharmacopoeia. Clarify the test operation flow, test parameters, preparation and calibration of work standards and criteria for judging results. According to the antibody titer detection method itself, select appropriate indicators to carry out methodological verification and establish verification scheme. Generally speaking, in terms of linearity, the correlation coefficient of neutralization titer determination method should meet the pre-set acceptable standards. In terms of accuracy, the ratio between the actual titer of neutralizing antibody and the theoretical titer of serum with different dilution times is 1, or the slope of regression line in covariance analysis is parallel. In terms of precision, the coefficient of variation should be controlled within 30% as far as possible. In terms of durability, it is necessary to investigate the effects of cell density (generation), neutralization virus dose, neutralization reaction conditions and time, and different positions of orifice plates on the test results. In order to study the influence of possible degradation products and degradation pathways on titer determination, the samples can be destroyed by accelerated methods such as strong light irradiation, high temperature and high humidity. Encourage the use of working standards as quality control, reduce test interference factors, and improve the accuracy and reliability of results.

Verification of detection methods for hazardous residues: Usually, hazardous residues are at trace level, and the sensitivity of detection methods determines the reliability of the results. Encourage the use of more advanced methods and instruments with higher sensitivity based on the methods in China Pharmacopoeia, and pay attention to distinguish the detection limits of instruments and methods. The obtained detection limit and quantitative limit data must be verified by samples with similar contents.
say
Test process and detection limit results, including accuracy and precision verification data. The linear indexes such as recovery rate (%) and relative standard deviation (RSD%) should be listed as regression equation, correlation coefficient, residual square sum linear graph, etc. The range should be drawn up within 20% of the specified limit according to the preliminary measured data, and in general, various methods with different principles should be used to verify each other. Methodological verification of product-related impurities: Methodological verification shall be carried out according to the requirements of China Pharmacopoeia. If the commercial kit is used for residue detection, it is suggested to study the selection of detection kit (such as IgA detection), and the detection kit should explain the sensitivity, specificity, detection limit, quantitative limit and linear range. In general, the accuracy, precision, linear range, interference test, reference interval and other indicators of the kit should be verified. The variation coefficient of precision should be within 20%, the accuracy deviation should not exceed 10%, the linear range determination coefficient (R 2) should be ≥ 0.98, and the relative deviation of interference test should be less than 10%. Attention should be paid to identify the factors that affect the accuracy of the determination results during the release test of products, such as pH value, PK activity, ionic strength of product solution, reaction temperature, etc., which will affect the determination results of PKA, and low pH conditions may reduce the PKA activity of products. 

6, reference (standard)

The quality control reference of antibody titer should be established according to the requirements of relevant guiding principles. When applying for NDA, it is necessary to clarify the key information such as the source and quality control of reference materials, and the reference materials should be related to the samples used in clinical experiments, paying attention to the accuracy and traceability of assignment. If international/national standards are adopted, the information of standards used (source, batch, etc.) shall be specified. If it is a self-made reference, the preparation process, calibration and stability should be studied.

(5) Stability study 

Stability test runs through the whole product life cycle and is the basis for formulating product standards and expiration dates. The stability test should be carried out in accordance with the China Pharmacopoeia and the relevant guiding principles of stability research of biological products at home and abroad. In the declaration stage of IND, preliminary stability inspection can be conducted to ensure the quality of samples in clinical stage. Complete a comprehensive stability inspection before NDA declaration, select suitable packaging materials, define storage and transportation conditions, and formulate a reasonable validity period. The investigation of influencing factor test and accelerated test should be studied as far as possible until the product is unqualified. Long-term stability investigation should extend the observation time of products as much as possible. In general, the liquid dosage form should be placed upside down and upright for stability test. Products with different closed systems should be tested for stability respectively. If a new production site is introduced to produce intermediate products, unless there are other reasons, the stability research of intermediate products and finished products should be carried out. The activity of Fc segment is an important indicator of the effectiveness of this kind of products, so it is suggested to investigate the related stability. For the special exemption products in liquid dosage form, the thermal stability test should be carried out, and the visible foreign bodies should be checked. The results should meet the requirements of China Pharmacopoeia.

(6) Packaging and sealing container system 

The source and control standard of inner packaging materials should be clarified, and the compatibility and sealing of packaging materials should be studied in accordance with the relevant guiding principles such as Technical Guiding Principles for Compatibility Research of Chemical Injection with Medical Glass Packaging Container (Trial Implementation), Technical Guiding Principles for Compatibility Research of Chemical Injection with Plastic Packaging Materials (Trial Implementation) and the requirements of ICH related guidelines. Extracts, dissolved substances, sloughs, etc. shall meet the limit requirements. Pay attention to the influence of the extract of inner packing rubber stopper and glass bottle on the preparation. 

V. Explanation of nouns

1. Blood Products refer to therapeutic products derived from human blood or plasma, such as human albumin, human immunoglobulin, human coagulation factor, etc.

2. Human Normal Immunoglobulin (HNIG): also known as gamma globulin or multivalent immunoglobulin, is an immunoglobulin preparation separated from healthy human plasma by low-temperature ethanol protein separation method or other approved protein separation methods, including intravenous immunoglobulin, intramuscular immunoglobulin and subcutaneous immunoglobulin.

3. Specific human immunoglobulin (HIG): It is a high titer immunoglobulin preparation prepared from plasma containing specific antibodies. The sources of plasma include plasma with high titer antibody after the patient recovered from infection with a pathogen, and plasma containing specific antibodies by hyperimmune injection of healthy blood donors, that is, injection of vaccines or other antigens to make the injected people produce antibodies. Different from ordinary immunoglobulins, such preparations must have at least one high titer antibody for the prevention and treatment of specific diseases in clinic.

4. Anti-complement Activity (ACA): A substance in serum or tissue fluid that can nonspecific bind to complement and make it inactive, such as protease and ester. 

VI. References (omitted)

Don’t get me wrong about these English (8)

Eminem, an American rapper, brought the film to perfection in the last part of his semi-autobiographical film "Eight Miles". Jimmy, who he played, won the championship in the impromptu rap contest in Detroit’s black area. When all the rappers waved their arms up and down with the music, you might feel excited. Many rappers saw this part and strengthened their belief in making Chinese rap music, but this English that made the audience high was easily misunderstood as other meanings.

1. bring down the house.

Get a house full of applause, not knock down the house.

Don't get me wrong about these English (8)

2. have a fit.

Lose one’s temper, fly into a rage, not trying on clothes

Don't get me wrong about these English (8)

3. make one’s hair stand on end.

It’s creepy, not outrageous.

Don't get me wrong about these English (8)

4. be taken in.

Deceived, not accepted.

Don't get me wrong about these English (8)

5. pull up one’s socks.

Courage, not socks.

Don't get me wrong about these English (8)

In a blink of an eye, 2013 is over half. How is your dream coming true? Courage to pursue your dream can be not only someone else’s business, but also your business. I also wish you pull up your socks and chase your dream. See you next week!

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Don’t get me wrong about these English meanings (1)

About the author:

Don't get me wrong about these English (8)

Leon, graduated from Harbin Institute of Technology, is a bilingual psychotherapist. Former editor-in-chief, good at American English, friends ashes powder, hobby HipHop and raising dogs. Now I live in Beijing and have my own psychological studio.

(Editor of China Daily English Dianjin Julie)

China’s economic development is full of stamina and keeps moving forward.

       CCTV News:Today (October 27th), News NetworkBroadcast a reportA number of data in China’s economic field have been published. Key words such as "growth" and "high level" have highlighted the overall development trend of China’s economy, and at the same time, other fields have also frequently achieved good results. The "big ship" of China’s economy will surely ride the wind and waves and continue to move forward.

In the third quarter, the profits of industrial enterprises nationwide increased by 7.7% year-on-year.

According to the data released by the National Bureau of Statistics today (October 27th), since the beginning of this year, with the continuous improvement of market demand and the steady growth of industrial production, the revenue and profits of industrial enterprises have continued to improve. Among them, the profits of industrial enterprises above designated size increased by 7.7% year-on-year in the third quarter, and the profits of industrial enterprises showed an accelerated recovery trend. On a monthly basis, in September, the profits of industrial enterprises above designated size increased by 11.9% year-on-year, achieving double-digit growth for two consecutive months.

The revenue of industrial enterprises has obviously improved. In the first three quarters, the operating income of industrial enterprises above designated size nationwide reached 96.35 trillion yuan, which was the same as that of the same period last year, and the growth rate was faster than that of the first half and the first quarter.

       In the third quarter, the profit of manufacturing industry increased by 11.8% year-on-year, of which the profit of raw material manufacturing industry increased by 60.8% year-on-year and the profit of consumer goods manufacturing industry increased by 11.8% year-on-year.

In the first three quarters, the investment scale of transportation fixed assets remained high.

According to the latest data released by the Ministry of Transport, in the first three quarters, China’s transportation fixed assets investment reached 2,877.5 billion yuan, a year-on-year increase of 5.6%, and the scale of transportation fixed assets investment remained high. Port cargo throughput also maintained rapid growth in the first three quarters. 1— In September, the total cargo throughput of ports nationwide was 12.54 billion tons, up 8.5% year-on-year, of which the foreign trade cargo throughput was 3.77 billion tons, up 10.1% year-on-year. Container throughput reached 230 million TEUs, up 5.2% year-on-year.

Data sorting out the achievements of the 134th Canton Fair.

The second phase of the 134th Canton Fair ended today (October 27th). Up to now, this year’s Canton Fair has carried out 53 "Bridge of Trade" global trade docking activities, attracting more than 220 buyers and more than 620 suppliers for "one-on-one" docking negotiations, with an intended purchase amount of about 100 million US dollars. Since the opening ceremony, more than 157,000 overseas buyers from 215 countries and regions have attended the meeting, an increase of 53.6% over the same period last year. Among them, there are more than 100,000 buyers in the "Belt and Road" countries, accounting for about 64%.

The third phase of the Canton Fair will be held from October 31st to November 4th, with more than 11,000 enterprises participating offline. The exhibition is divided into five sections: toys and pregnant babies, fashion, household textiles, stationery and health and leisure.

In October in Yangcheng, all merchants gather. In Guangzhou these days, not only is the booth crowded, but many hotels in the city are also hard to find a room. Against the background of sluggish demand in the world economy, such a scene is very emotional. The bustling passenger flow is people’s confidence in China’s economy.

The 24th Central China Agricultural Expo opened.

       The 24th Central China Agricultural Expo opened today in Changsha, Hunan. This year’s Expo set up special exhibition halls such as the Central Inter-provincial Pavilion and the Agricultural Service Pavilion, which attracted nearly 5,000 enterprises to focus on the exhibition and sale of high-quality agricultural products. During the exhibition, China Central Agricultural Brand Promotion Conference and other activities will be held.

The latest scientific and technological achievements of start-up technology enterprises are concentrated in appearance.

Recently, the 17th Innovation China was held in Beijing Shougang Park. Nearly 100 outstanding start-up technology enterprises from all over the country brought their latest scientific and technological achievements to the show. Focusing on the theme of artificial intelligence, this activity covers intelligent manufacturing, life sciences, new energy and green economy, intelligent interconnection and new businesses. Since the launch of the activity in 2006, more than 1000 investors have been gathered to connect with entrepreneurs on the spot to help the entrepreneurial team grow rapidly.

In the third quarter, civil aviation completed 180 million passenger trips.

In the third quarter, China’s civil aviation maintained a safe and orderly recovery trend, and transportation production continued to improve. The total transportation turnover of the whole industry was 33.68 billion tons kilometers, an increase of 89.3% year-on-year; There is a strong demand in the passenger transport market. The whole industry has completed a total of 180 million passenger trips, up 108.3% year-on-year, and the passenger transport scale of the industry has reached a quarterly record high.

This year, China’s digital supply chain market will exceed 32 trillion.

The relevant person in charge of China Federation of Logistics and Purchasing introduced at the 6th Digital Supply Chain Platform Development Conference today (October 27th) that China’s economy is recovering continuously and its growth momentum has been enhanced. Under the background of accelerating the reconstruction of the global industrial chain supply chain, the development of China’s digital supply chain platform has entered the fast lane.

According to the relevant person in charge of China Federation of Logistics and Purchasing, it is estimated that as the largest manufacturing and consumer market in the world, the market size of China’s digital supply chain will increase from 8.25 trillion yuan in 2018 to 27.2 trillion yuan in 2022, with a compound annual growth rate of 26.94%. In 2023, the market size of digital supply chain will exceed 32 trillion yuan. The security and stability of the supply chain provides strong support for smooth double circulation, promoting high-quality economic development and enhancing international competitiveness.

China has boosted the global mining market to stabilize and recover.

The Global Mining Development Report 2023 shows that China’s economy has recovered rapidly, and the demand for mineral resources has remained high, effectively stimulating the global consumption demand for energy resources.

       According to the latest data, in 2022, with the global demand for mineral resources shrinking, China’s energy and mineral resources remained stable and its consumption continued to grow, which played an important role in stabilizing the global mining market. For example, in 2022, China’s coal consumption reached 3.041 billion tons, a year-on-year increase of 4.3%. The domestic coal production capacity was released steadily, and the coal mine operating rate remained high, with the annual output reaching 4.496 billion tons, up 9% year-on-year.

In the first three quarters, residents spent a total of 3.69 trillion yuan on domestic trips.

       The Ministry of Culture and Tourism released the data of domestic tourism in the first three quarters of 2023 today (October 27). According to the statistical results of domestic tourism sampling survey, the total number of domestic tourists in the first three quarters of this year was 3.674 billion, an increase of 1.58 billion over the same period of last year and a year-on-year increase of 75.5%. In the first three quarters, residents spent 3.69 trillion yuan on domestic trips, an increase of 1.97 trillion yuan or 114.4% over the previous year.

Ministry of Commerce: I am confident to achieve the goal of promoting stability and improving quality of foreign trade throughout the year.

On October 26th, the Ministry of Commerce held a regular press conference. The spokesman said that China’s foreign trade is running smoothly on the whole, and it is confident to achieve the goal of promoting stability and improving quality of foreign trade throughout the year.

The Ministry of Commerce said that since the beginning of this year, due to high inflation, high inventory and geopolitical risks, global trade has continued to be weak. According to the data of the World Trade Organization (WTO), global exports fell by 4.6% in the first half of the year. Based on concerns about growth difficulties and challenges, the WTO recently lowered the growth rate of global merchandise trade in 2023 from the previous forecast of 1.7% to 0.8%.

In the face of multiple risk challenges, China has solidly promoted the policy of stabilizing foreign trade, and China’s foreign trade has generally operated smoothly, especially in recent months.

Shu Yuting, spokesperson of the Ministry of Commerce:In terms of scale, China’s import and export scale rose quarter by quarter, and increased month by month in the third quarter. In September, the import and export volume reached a single-month high in the year. In terms of share, WTO data show that China’s export international market share reached 14.2% in the first half of the year, 0.4 percentage points higher than the same period last year.

From the main point of view, the number of foreign trade enterprises with import and export performance in the first three quarters was 597 thousand, which was close to the level of last year. From the perspective of kinetic energy, superior products such as automobiles, ships, lithium batteries and luggage maintained a relatively high growth rate, and new cross-border e-commerce formats continued to contribute to the increase.

Shu Yuting, spokesperson of the Ministry of Commerce:These positive changes are inseparable from the persistence and innovation of the majority of foreign trade subjects, the effective implementation of stable foreign trade policies, and the resilience and vitality of China’s foreign trade. With the continuous accumulation of positive factors, we are confident that we will continue to consolidate the good operation situation in the fourth quarter and we are confident that we will achieve the goal of promoting stability and improving quality of foreign trade throughout the year.

In addition, recently, the National Data Bureau was established. The newly established National Data Bureau is responsible for coordinating and promoting the construction of data infrastructure, coordinating the integration, sharing, development and utilization of data resources, and coordinating the planning and construction of digital China, digital economy and digital society. 

Sharp l sales plummeted, abnormal sound, gearbox frustration, car machine not updated into pain points

L Hybrid Since then, with the blessing of a new hybrid system,Changed consumers’ inherent impression of American fare oil.Coupled with the appearance of the atmosphere and good control, it has won the support of many consumers. However, with the passage of time, many car owners reported the existence of the car.qualityproblem

Recently, a Mr. Chen from Haikou, Hainan, told the Chief of Staff about the car feedback:

In April 2024, I bought a Ford Sharp L. Soon after I picked up the car, I found that when the vehicle was in the starting state, when it was at low speed or when it was accelerating or decelerating, it would send out ".Cough cough "The voice.

in additionA Mr. Li from alsoTo the chief of staffTalking about car feedback

In addition to abnormal sound, lThe gearbox still has a setback problem.The driving experience is a bit poor.

Going to the 4S shop for inspection, the after-sales staff explained: "This voicenormal, yesGear-driven",and said that the test drive also has this voice.

Faced with the helplessness of the 4S shop, the above two car owners were very confused and anxious, questioning why a car manufacturer could not repair the car?

I often listen to this questionThe chief of staff said that all riders on the car show know that the main reason is thatLack of experience in the field of mixingIt is difficult to cope with all kinds of complicated problems in actual use.

But cars, as a mass consumer product,And gearbox, as one of its core components, the problem of failure can not be ignored. WeHope Chang ‘an FordActively communicate with users to find solutions.Otherwise, it will reduce users’ trust in the brand.

Besides the gearbox problem,The car has not been updated for a long time and the navigation version is old.It is also the hardest hit area for vehicle complaints.

Many old car owners reported:

The locomotive system has not been updated for two or three years., there is a phenomenon of caton;The navigation version is old.Many routes are not accurately navigated; When buying a carOfficial propaganda can be connected to mobile phones, but as of today, this function is still not supported.



There are also some sharp car owners who have feedback:The front and rear doors are uneven, the chassis/exhaust pipe is rusted, the car crashes/black screen, and the engine lights up.











The above complaints from car owners have undoubtedly had a certain impact on the sales of Sharp L.

It is understood that from January to May 2024, the cumulative sales volume of Sharp L was 9,768 vehicles.It decreased by 61.7% year on year.. (This is just a microcosm of Changan Ford’s models. )

after allNowadays, consumers are more rational in buying cars and pay more attention to the quality and reliability of vehicles..

When a brand has frequent quality problems, it will definitely flinch and choose other brands with more quality assurance. Even former loyal fans may turn to other competitors because of their concerns about quality.


Therefore, if Changan Ford wants to get rid of the current predicament and regain the market share and the trust of consumers, it must face up to the quality problems and improve the quality control and after-sales maintenance level of its models. Only in this way can we achieve a counterattack in the fierce market competition and return to the track of sales growth.

Today’s topic:After reading this article, will you still buy Ford Sharp L?Please leave a message in the comments section.

Reading: Where is the application entrance of Huawei HarmonyOS system? Introduction to the application entrance of Huawei HarmonyOS system [Detailed explanation] Where is the application entrance of H

  As we all know, except for Apple’s ios system, other brands of mobile phone operating systems are developed and changed based on Android system. Recently, however, Huawei finally pushed the HarmonyOS System 2.0 beta version developed by Huawei. Friends who want to test can apply for developers for free and participate in the test. Let’s take a look at the specific methods below.

  1. First, click "Huawei" on Huawei’s mobile phone to enter the application.

  2. Then click "Upgrade early adopters"

  3. Find and click "Try it now", as shown in the figure.

  4. Find the model of your mobile phone and click "Register for public beta".

  5. After agreeing to a series of agreements, you can download the description file.

  6. After downloading the description file, enter "System and Update" in the phone settings.

  7. Enter "Software Update" to download and update the HarmonyOS system.

  8. At present, the models that can be updated are: Huawei Mate 40 series, Mate 30 series, P40 series, Mate X2 and MatePad Pro.

  1. If our mobile phone has not been added to the latest test list, we can participate in the beta test. After registering as a developer, you can sign up for the test on the website. [Huawei HarmonyOS Test]

  2. We can pay attention to WeChat official account, the developer of HarmonyOS.

  3. Then click "B eta beta" below.

  4. You can register to become a developer for free.

  6. At present, the test models that can participate are: Huawei P40, P40 Pro, Mate 30, Mate 30 Pro, MatePad Pro, and there is no latest Mate 40 series.

  1. How to upgrade HarmonyOS 2.0 to 3.0?

  Click on the phone settings, then enter the software update, find the corresponding page, click on the update, download, upgrade and install.

  2, HarmonyOS charging prompt tone setting tutorial

  Open the Smart Assistant and select the charging tone, and then you can set and operate it in this page.

Putin: This weapon makes the enemy "think twice before you act"

  The reference news network reported on September 6. According to the US Newsweek website reported on September 2, after Russia said that it had put an advanced intercontinental ballistic missile (ICBM) into military service, Russia stepped up its nuclear rhetoric. Putin once said that this missile will make Moscow’s enemies "think twice before you act."

  According to the official Russian news agency Tass, Yuri borisov, head of the Russian National Aerospace Group, said that the "sarmat" intercontinental ballistic missile had "taken up the combat mission".

  What is "sarmat" intercontinental ballistic missile?

  RS-28 sarmat is a liquid-fueled intercontinental ballistic missile produced by Russian Makeyev Rocket Design Bureau.

  This missile was originally designed to replace the R-36 intercontinental ballistic missile with a range of 9940 miles (1 mile is about 1.6 kilometers). NATO calls R-36 Satan, so its successor model is usually informally called Satan 2.

  The RS-28 sarmat missile is 116 feet long and weighs 220 tons. It is said that it can carry up to 15 light nuclear warheads. This missile has a range of 11,000 miles and can strike targets in the United States and Europe.

  In contrast, the American LGM-30 Militia intercontinental ballistic missile weighs about 36 tons, has a range of about 8,100 miles and a diameter of 5.5 feet (about 4 feet smaller than that of sarmat).

  Sarmat is a missile based on silo. It is believed that its initial launch stage is very short, which means that the monitoring system has little time to track its launch.

  On April 20, 2022, Russia test-fired this missile from Plesetsk, Arkhangelsk region, 500 miles north of Moscow. It is reported that the missile hit the target on the kamchatka peninsula, which is 3,700 miles away from the Russian Far East.

  As a part of the "next generation" nuclear missile technology, the "sarmat" intercontinental ballistic missile is one of six new Russian strategic weapons announced by Putin in his State of the Union address on March 1, 2018.

  After the first successful test launch in April 2022 (the United States has been informed of the test launch in advance), Putin said that the missile has "the highest tactical and technical characteristics and can overcome all modern anti-missile defense means."

  He said that the missile is unique in the world and "there will be no similar weapons for a long time to come". Putin also said that this weapon will make those who try to threaten Russia "think twice before you act."

  On the Russian -1 Channel’s "60 Minutes" program, Alexei Zhuravlev, chairman of the nationalist party Motherland Party, said that as long as there is a "sarmat" missile, "the British Isles will cease to exist".

  However, Pavel Podvig, who is in charge of the research project of "Russian Nuclear Forces" in Geneva, wrote on the X website (the former Twitter website) that in February this year, Russia’s second test-fired "sarmat" intercontinental ballistic missile failed due to a secondary fault. He wrote: "Besides, people have other questions. So before it was confirmed, we returned to a state of success, failure and no deployment. " (Compile/Yang Xuelei)